DrugDecide OncoDrug Panels

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DrugDecide OncoDrug Panels

Pharmacogenomics

Individual variability in drug efficacy and drug safety is a major challenge in current clinical practice, drug development, and drug regulation.
Pharmacogenomics and personalised drug therapy, both are increasingly influencing cancer treatment, recently. Personalized therapy for cancer is one in which the chemotherapy regimen is chosen based partly on genetic tests of the patient.
In majority cases, presence of single nucleotide polymorphisms (SNPs) in the sequence of the genes encoding proteins that are involved in metabolism of anti-cancer drug are attributed to inter individual variability in drug response.

Drug Decide Kits-Drugwise

  • Tamoxifen
  • Irinotecan
  • Paclitaxel
  • Cyclophosphamide Carboplatin Docetaxel Capecitabine Fluorouracil Pyrimidine analogues Leucovorin Oxaliplatin Cisplatin Methotrexate
  • Pemetrexed

The clinical annotation level of evidence of all SNP’s in Drug Decide Kits are above Moderate (level 2) to High (level1). Variants from Level 3 and 4 are not included as there is no statistically significant association established for these level variant-drug combinations.

DrugDecide panels details

DrugDecide series provides allelic discrimination real time PCR which uses a pair of primer with two fluorogenic probes based chemistry that discriminates mutant allele from wild type in a single tube.
The kit includes all the reagents from sample to SNP detection. A combination of robust reagents for DNA extraction from clinical samples and validated primers, hydrolysis probes as well as hot start Taq polymerase for SNP detection ensures that kit leads to highly specific and sensitive results in short time.

Kit Features

  • Highly Sensitive SNP Screening kits
  • Multiplex analysis with no need for optimization- Detects Wild and Mutant type in one go
  • Easy workflow with ready-to-use solutions and optimal quality control
  • Simple reaction setup and data interpretation
  • Includes the entire reagent required to perform Sample to Result analysis no additional reagents needed.
  • Results aligned with Wild and Mutant controls included with the kit.
  • Low contamination risk – no post-PCR product handling
  • High-throughput and Fast – results in under 80 minutes after PCR start

Kit Contents

  • Reagents for isolating DNA from blood samples
  • Reagents required SNP screening on RTPCR
  • Validated reaction controls