HER2 DNA Amplification Kit

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HER2 DNA Amplification Kit

HER-2 is a proto-oncogene located at 17q21 that encodes a 185-kd transmembrane glycoprotein with tyrosine kinase activity. HER-2 (also known as c-erbB-2 or neu) is a member of the epidermal growth factor receptor family and is now recognized as a key oncogene in several malignancies.

HER2 gene amplification is the primary mechanism for HER2 overexpression which occurs in 18–20% of invasive breast cancer. It is regarded as a marker of adverse clinical outcome and as a predictive marker for reduced response to certain chemotherapy and hormonal treatments. Even more importantly, positive HER-2 status predicts for response to therapy with trastuzumab (Herceptin), which is effective in prolonging patient’s survival with receptor positive metastatic breast carcinoma.

Thus reliable and robust method for determining Her2 status in breast carcinomas has a clinical benefit.

Kit Features

  • Highly sensitive and specific HER2 DNA amplification kit
  • Easy workflow with ready-to-use solutions
  • Positive standatds are provided for both HER2 and reference gene for quantitative and accurate results
  • Simple reaction setup and data interpretation
  • Includes the entire reagents to perform sample to result analysis
  • Low comunication risk-no post-PCR product handling
  • High-throughput and Fast-result in under 80 minutes after PCR start

Kit Details

Mylab Discovery Solutions provides quantitative real-time PCR assay for detection of HER2 DNA amplification. The HER2 gene is amplified in parallel with a reference gene in a single tube and the copy-number ratio between HER2 and the reference gene is analysed. It is very simple, sensitive, reproducible method for HER2 detection and quantitation.

Kit Contents

  • Reagents for isolating DNA from Clinical samples
  • Reagents required for screeening og KRAS mutations using RTPCR
  • Validated reaction controls

Order Information

# Product Cat. No. Reaction size/kit
1 Oncoscreen HER2 DNA Amplification Kit OHR25 25
2 Oncoscreen HER2 DNA Amplification Kit OHR50 50